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PVAR3D
DNA gyrase subunit A - Q2G2Q0
Model based on:
Entry features
Model PirFile Alignment Superimposition Procheck MSA
GENE DNA gyrase subunit A
ORGANISM Staphylococcus aureus (strain NCTC 8325)
TAXONOMY Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus.
UNIPROT Q2G2Q0
Template 6fqv A
RESISTANCE fluoroquinolone
Cross-references
STRING 93061.SAOUHSC_00006
REFSEQ WP_000819084.1; NZ_LS483365.1; YP_498614.1; NC_007795.1
PFAM PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C
PATRIC fig|93061.5.peg.6
KEGG sao:SAOUHSC_00006
EMBL CP000253; ABD29197.1
BioCyc/EcoCyc/MetaCyc SAUR93061:G1G5Y-6-MONOMER
EC 5.99.1.3
Active site 123 123 O-(5'-phospho-DNA)-tyrosine intermediate

Gene Ontology
Molecular Function GO ID Term Evidence
GO:0003677 F:DNA binding IEA
GO:0003918 F:DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
GO:0005524 F:ATP binding IEA
Biological Process GO ID Term Evidence
GO:0006261 P:DNA-dependent DNA replication IEA
GO:0006265 P:DNA topological change IEA
GO:0046677 P:response to antibiotic IEA
Cellular Component GO ID Term Evidence
GO:0005694 C:chromosome IEA
GO:0005737 C:cytoplasm IEA
Mutation panel
Mutation Phenotype Reference Map mutation on Model
E88K fluoroquinolone PMID:NA 79
Sequence
Multiple sequence alignment
MSA Mutation
Variant Position in MSA
E88K 156