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PVAR3D
parC - P0C1U9
Model based on:
Entry features
Model PirFile Alignment Superimposition Procheck
GENE parC
DESCRIPTION Topoisomerase IV subunit A
ORGANISM Staphylococcus aureus
TAXONOMY Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus.
UNIPROT P0C1U9
Template 2inr A
Cross-references
REFSEQ WP_001289554.1; NZ_PZYG01000012.1
PFAM PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C
PATRIC fig|1280.3364.peg.2251
EMBL D67074; BAA11085.1; L25288; AAA53116.1
EC 5.99.1.3
Drugbank DB00537 - Ciprofloxacin
CHEMBL CHEMBL4088
Active site 119 119 O-(5'-phospho-DNA)-tyrosine intermediate

Gene Ontology
Molecular Function GO ID Term Evidence
GO:0003677 F:DNA binding IEA
GO:0003918 F:DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
GO:0005524 F:ATP binding IEA
Biological Process GO ID Term Evidence
GO:0006265 P:DNA topological change IEA
GO:0007059 P:chromosome segregation IEA
GO:0046677 P:response to antibiotic IEA
Cellular Component GO ID Term Evidence
GO:0005694 C:chromosome IEA
GO:0019897 C:extrinsic component of plasma membrane IEA
Mutation panel
Mutation Phenotype Reference Map mutation on Model
F80S

(non-resistant)

In strain: FDA 574 		PMID:NA 51
K84E

(non-resistant)

In strain: FDA 574 		PMID:NA 55
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available