gyrA - ARO:3004334-NP_461214.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Salmonella. |
| UNIPROT | P37411 |
| NCBI | NP_461214.1 |
| ARO term | ARO:3004334 |
| Template | 4tma C |
| RESISTANCE | fluoroquinolone; nybomycin; triclosan |
Cross-references
| STRING | 99287.STM2272 | |
|---|---|---|
| REFSEQ | NP_461214.1; NC_003197.2; WP_001281271.1 | |
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|99287.12.peg.2405 | |
| KEGG | stm:STM2272 | |
| EMBL | AE006468; AAL21173.1; X78977; CAA55580.1; X86695; CAA60388.1 | |
| BioCyc/EcoCyc/MetaCyc | SENT99287:G1FZD-2293-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01897 | |
| Active site | 122 122 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D87G | resistant | PMID:29091182 | 68 |
| S83F | resistant | PMID:29091182 | 64 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D87G | 88 |
| S83F | 84 |