gyrA - ARO:3003995-YP_001086469.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Clostridium difficile 630 |
| TAXONOMY | Bacteria; Firmicutes; Clostridia; Clostridiales;Peptostreptococcaceae; Clostridioides. |
| UNIPROT | Q18C90 |
| NCBI | YP_001086469.1 |
| ARO term | ARO:3003995 |
| Template | 4ddq A |
| RESISTANCE | fluoroquinolone; nybomycin |
Cross-references
| STRING | 272563.CD0006 | |
|---|---|---|
| REFSEQ | WP_003429305.1; NZ_CP010905.2; YP_001086469.1; NC_009089.1 | |
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|272563.120.peg.6 | |
| KEGG | cdf:CD630_00060; pdc:CDIF630_00006 | |
| EMBL | AM180355; CAJ66820.1 | |
| BioCyc/EcoCyc/MetaCyc | PDIF272563:G12WB-6-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01897 ; ECO:0000256| SAAS:SAAS00993472 | |
| Active site | 121 121 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| A384D | resistant | PMID:27842877 | 355 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A384D | 455 |