parC - ARO:3003939-NP_462089.1
Model based on:
Entry features
| GENE | parC | |
|---|---|---|
| DESCRIPTION | Topoisomerase IV subunit A | |
| ORGANISM | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Salmonella. | |
| UNIPROT | P26973 | |
| NCBI | NP_462089.1 | |
| ARO term | ARO:3003939 | |
| Template | 1zvu A | |
| RESISTANCE | ciprofloxacin; fluoroquinolone; nalidixic acid |
Cross-references
| STRING | 99287.STM3174 | |
|---|---|---|
| REFSEQ | NP_462089.1; NC_003197.2; WP_001281908.1 | |
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|99287.12.peg.3365 | |
| KEGG | stm:STM3174 | |
| EMBL | AE006468; AAL22048.1; M68936; AAA27180.1 | |
| BioCyc/EcoCyc/MetaCyc | SENT99287:G1FZD-3208-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_00936 | |
| Active site | 120 120 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0007059 | P:chromosome segregation | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0019897 | C:extrinsic component of plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| W106G | resistant | PMID:27630841 | 79 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| W106G | 113 |