PBP2 - ARO:3003937-NP_273462.1
Model based on:
Entry features
| GENE | PBP2 | |
|---|---|---|
| DESCRIPTION | Penicillin-binding protein 2 | |
| ORGANISM | Neisseria meningitidis MC58 | |
| TAXONOMY | Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;Neisseriaceae; Neisseria. | |
| UNIPROT | P0A0U9 | |
| NCBI | NP_273462.1 | |
| ARO term | ARO:3003937 | |
| Template | 3equ B | |
| RESISTANCE | carbapenem; cefixime; ceftriaxone; cephalosporin; cephamycin; monobactam; penam |
Cross-references
| STRING | 122586.NMB0413 | |
|---|---|---|
| REFSEQ | NP_273462.1; NC_003112.2; WP_002218783.1 | |
| PFAM | PF00905 - Transpeptidase; PF03717 - PBP_dimer | |
| PATRIC | fig|122586.8.peg.523 | |
| KEGG | nme:NMB0413 | |
| EMBL | AE002098; AAF40852.1; X15276; CAA33347.1 | |
| BioCyc/EcoCyc/MetaCyc | NMEN122586:G1G1B-408-MONOMER | |
| EC | 3.4.16.4 | |
| Catalytic activity | Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|- D-Ala; Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine| Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine | |
| Active site | 310 310 Acyl-ester intermediate | |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_02080}. |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008658 | F:penicillin binding | IEA | |
| GO:0008955 | F:peptidoglycan glycosyltransferase activity | IEA | |
| GO:0009002 | F:serine-type D-Ala-D-Ala carboxypeptidase activity | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0008360 | P:regulation of cell shape | IEA | |
| GO:0009252 | P:peptidoglycan biosynthetic process | IEA | |
| GO:0043093 | P:FtsZ-dependent cytokinesis | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| GO:0071555 | P:cell wall organization | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005887 | C:integral component of plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| A501P | resistant | PMID:25199775 | 37 |
| A510V | resistant | PMID:25987627 | 46 |
| F504L | resistant | PMID:26787702 | 40 |
| G482S | resistant | PMID:18986991 | 18 |
| G545S | resistant | PMID:16940068 | 81 |
| I312M | resistant | PMID:16940068 | - |
| N512Y | resistant | PMID:25987627 | 48 |
| V316T | resistant | PMID:16940068 | - |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A501P | 501 |
| A510V | 510 |
| F504L | 504 |
| G482S | 482 |
| G545S | 545 |
| I312M | 312 |
| N512Y | 512 |
| V316T | 316 |