gyrA - ARO:3003928-YP_207769.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Neisseria gonorrhoeae FA 1090 |
| TAXONOMY | Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;Neisseriaceae; Neisseria. |
| UNIPROT | Q5F8Y0 |
| NCBI | YP_207769.1 |
| ARO term | ARO:3003928 |
| Template | 4ckk C |
| RESISTANCE | fluoroquinolone; nybomycin |
Cross-references
| REFSEQ | WP_003692988.1; NC_002946.2; YP_207769.1 | |
|---|---|---|
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|242231.10.peg.743 | |
| KEGG | ngo:NGO0629 | |
| EMBL | AE004969; AAW89357.1 | |
| BioCyc/EcoCyc/MetaCyc | NGON242231:G1FZ9-589-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01897 ; ECO:0000256| SAAS:SAAS00993472 | |
| Active site | 130 130 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D95G | resistant | PMID:27506605 | 55 |
| D95N | resistant | PMID:27506605 | 55 |
| S91F | resistant | PMID:27506605 | 51 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available