gyrA - ARO:3003924-WP_014065640.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Haemophilus parainfluenzae |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;Pasteurellaceae; Haemophilus. |
| UNIPROT | E1W6N3 |
| NCBI | WP_014065640.1 |
| ARO term | ARO:3003924 |
| Template | 4tma C |
| RESISTANCE | fluoroquinolone; nybomycin |
Cross-references
| STRING | 862965.PARA_19270 | |
|---|---|---|
| REFSEQ | WP_014065640.1; NC_015964.1 | |
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|862965.3.peg.1919 | |
| KEGG | hpr:PARA_19270 | |
| EMBL | FQ312002; CBW16027.1 | |
| BioCyc/EcoCyc/MetaCyc | HPAR862965:G1GWU-1978-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01897 ; ECO:0000256| SAAS:SAAS00993472 | |
| Active site | 123 123 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| S84Y | resistant | PMID:PMID in progress (single) | 64 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| S84Y | 84 |