gyrA - ARO:3003702-BAA37152.1
Model based on:
Entry features
| GENE | gyrA | |
|---|---|---|
| DESCRIPTION | Topoisomerase IV subunit A | |
| ORGANISM | Pseudomonas aeruginosa | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;Pseudomonadaceae; Pseudomonas. | |
| UNIPROT | Q9ZNQ0 | |
| NCBI | BAA37152.1 | |
| ARO term | ARO:3003702 | |
| Template | 1zvu A | |
| RESISTANCE | fluoroquinolone; nybomycin |
Cross-references
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
|---|---|---|
| EMBL | AB003428; BAA37152.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_00936 ; ECO:0000256| SAAS:SAAS00993472 | |
| Active site | 127 127 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0007059 | P:chromosome segregation | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0019897 | C:extrinsic component of plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| S80L | resistant | PMID:22821356 | 46 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| S80L | 80 |