parE - ARO:3003685-NP_253654.1
Model based on:
Entry features
| GENE | parE | |
|---|---|---|
| DESCRIPTION | Topoisomerase IV subunit B | |
| ORGANISM | Pseudomonas aeruginosa PAO1 | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;Pseudomonadaceae; Pseudomonas. | |
| UNIPROT | Q9HUJ8 | |
| NCBI | NP_253654.1 | |
| ARO term | ARO:3003685 | |
| Template | 4juo C | |
| RESISTANCE | fluoroquinolone |
Cross-references
| STRING | 208964.PA4967 | |
|---|---|---|
| REFSEQ | NP_253654.1; NC_002516.2; WP_003102062.1 | |
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|208964.12.peg.5201 | |
| KEGG | pae:PA4967 | |
| EMBL | AE004091; AAG08352.1 | |
| BioCyc/EcoCyc/MetaCyc | PAER208964:G1FZ6-5083-MONOMER | |
| EC | 5.99.1.3 | |
| CHEMBL | CHEMBL3390827 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_00938 | |
| NUCLEOTIDE BINDING | 109 115 ATP |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IDA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IDA | |
| GO:0007059 | P:chromosome segregation | IBA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0009295 | C:nucleoid | IBA | |
| GO:0009340 | C:DNA topoisomerase IV complex | IDA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| A473V | resistant | PMID:23274661 | 457 |
| M437I | resistant | PMID:23274661 | 421 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A473V | 474 |
| M437I | 438 |