gyrB - ARO:3003459-CAA55486.1
Model based on:
Entry features
| GENE | gyrB |
|---|---|
| ORGANISM | Mycobacterium tuberculosis H37Ra |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. |
| UNIPROT | A5TY73 |
| NCBI | CAA55486.1 |
| ARO term | ARO:3003459 |
| Template | 3zkd F |
| RESISTANCE | aminocoumarin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| STRING | 419947.MtubH3_010100016152 | |
|---|---|---|
| REFSEQ | WP_003917863.1; NZ_CP016972.1 | |
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| KEGG | mra:MRA_0005 | |
| EMBL | CP000611; ABQ71723.1; ALT_INIT; X78888; CAA55486.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01898 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D500H | resistant | PMID:22761889 | - |
| E540D | resistant | PMID:22761889 | - |
| E540V | resistant | PMID:22761889 | - |
| N510D | resistant | PMID:16377674 | - |
| N538D | resistant | PMID:22761889 | - |
| N538D,T546M | resistant | PMID:22761889 | - |
| N538K | resistant | PMID:22761889 | - |
| N538T,T546M | resistant | PMID:22761889 | - |
| R485C,T539N | resistant | PMID:22761889 | - |
| R485C,T546M | resistant | PMID:PMID in progress (multiple) | - |
| T539N | resistant | PMID:22761889 | - |
| T539P | resistant | PMID:22761889 | - |
| V340L | resistant | PMID:22761889 | 292 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D500H | 515 |
| E540D | 555 |
| E540V | 555 |
| N510D | 525 |
| N538D | 553 |
| N538D;T546M | 553;561 |
| N538K | 553 |
| N538T;T546M | 553;561 |
| R485C;T539N | 500;554 |
| R485C;T546M | 500;561 |
| T539N | 554 |
| T539P | 554 |
| V340L | 355 |