ethA - ARO:3003458-AAK48336.1
Model based on:
Entry features
| GENE | ethA | |
|---|---|---|
| DESCRIPTION | Baeyer-Villiger monooxygenase EtaA | |
| ORGANISM | Mycobacterium tuberculosis CDC1551 | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. | |
| UNIPROT | P9WNF8 | |
| NCBI | AAK48336.1 | |
| ARO term | ARO:3003458 | |
| Template | 4aox A | |
| RESISTANCE | ethionamide; isoniazid |
Cross-references
| REFSEQ | WP_003899731.1; NZ_KK341227.1 | |
|---|---|---|
| PFAM | PF00743 - FMO-like | |
| PATRIC | fig|83331.31.peg.4268 | |
| KEGG | mtc:MT3969 | |
| EMBL | AE000516; AAK48336.1 | |
| EC | 1.14.13.- | |
| Catalytic activity | Ethionamide + NADPH + O(2) = ethionamide S- oxide + NADP(+) + H(2)O; ECO:0000250| UniProtKB:P9WNF9 | |
| NUCLEOTIDE BINDING | 183 189 NADP; 207 208 NADP; 44 47 FAD; 54 56 NADP |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004499 | F:N,N-dimethylaniline monooxygenase activity | IEA | |
| GO:0050660 | F:flavin adenine dinucleotide binding | IEA | |
| GO:0050661 | F:NADP binding | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005886 | C:plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| A381P | resistant | PMID:10944230 | 380 |
| D55A | resistant | PMID:14638486 | 54 |
| D58A | resistant | PMID:10944230 | 57 |
| E223K | resistant | PMID:14638486 | 222 |
| G385D | resistant | PMID:14638486 | 384 |
| G413D | resistant | PMID:14638486 | 412 |
| G43C | resistant | PMID:10944230 | 42 |
| G43S | resistant | PMID:14638486 | 42 |
| I338S | resistant | PMID:14638486 | 337 |
| P51L | resistant | PMID:10944230 | 50 |
| R463S | resistant | PMID:14638486 | - |
| T186K | resistant | PMID:10944230 | 185 |
| T342K | resistant | PMID:10944230 | 341 |
| T392A | resistant | PMID:14638486 | 391 |
| Y84D | resistant | PMID:10944230 | 83 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A381P | 381 |
| D55A | 55 |
| D58A | 58 |
| E223K | 223 |
| G385D | 385 |
| G413D | 413 |
| G43C | 43 |
| G43S | 43 |
| I338S | 338 |
| P51L | 51 |
| R463S | 463 |
| T186K | 186 |
| T342K | 342 |
| T392A | 392 |
| Y84D | 84 |