rpsL - ARO:3003395-AAK44936.1
Model based on:
Entry features
| GENE | rpsL |
|---|---|
| ORGANISM | Mycobacterium tuberculosis CDC1551 |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. |
| UNIPROT | P9WH62 |
| NCBI | AAK44936.1 |
| ARO term | ARO:3003395 |
| Template | 1vy5 L |
| RESISTANCE | aminoglycoside; streptomycin |
Cross-references
| REFSEQ | WP_003403453.1; NZ_KK341227.1 |
|---|---|
| PFAM | PF00164 - Ribosom_S12_S23 |
| PATRIC | fig|83331.31.peg.758 |
| KEGG | mtc:MT0710 |
| EMBL | AE000516; AAK44936.1 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0000049 | F:tRNA binding | IEA | |
| GO:0003735 | F:structural constituent of ribosome | IEA | |
| GO:0019843 | F:rRNA binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006412 | P:translation | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0015935 | C:small ribosomal subunit | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| K43R | resistant | PMID:15305490 PMID:22943573 | 42 |
| K88Q | resistant | PMID:22943573 | 87 |
| K88R | resistant | PMID:22943573 | 87 |
| T40I | resistant | PMID:15305490 | 39 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| K43R | 43 |
| K88Q | 88 |
| K88R | 88 |
| T40I | 40 |