folP - ARO:3003389-CAC29732.1
Model based on:
Entry features
| GENE | folP | |
|---|---|---|
| DESCRIPTION | Dihydropteroate pyrophosphorylase | |
| ORGANISM | Mycobacterium leprae TN | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium. | |
| UNIPROT | P0C0X1 | |
| NCBI | CAC29732.1 | |
| ARO term | ARO:3003389 | |
| Template | 1eye A | |
| RESISTANCE | dapsone; sulfonamide; sulfone |
Cross-references
| STRING | 272631.ML0224 | |
|---|---|---|
| REFSEQ | NP_301284.1; NC_002677.1; WP_010907608.1 | |
| PFAM | PF00809 - Pterin_bind | |
| PATRIC | fig|272631.5.peg.356 | |
| KEGG | mle:ML0224 | |
| EMBL | AB028660; BAA84078.1; AB028657; BAA84075.1; AL023093; CAA18794.1; AB028658; BAA84076.1; AB028659; BAA84077.1; AL583917; CAC29732.1; AB028662; BAA84080.1; AF117618; AAF06725.1; AB028656; BAA84074.1; AB028661; BAA84079.1; AB028663; BAA84081.1 | |
| BioCyc/EcoCyc/MetaCyc | MLEP272631:G1GT5-255-MONOMER | |
| EC | 2.5.1.15 | |
| Drugbank | DB00250 - Dapsone | |
| CHEMBL | CHEMBL2362993 | |
| Catalytic activity | 6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate; ECO:0000269| PubMed:10542185 | |
| PATHWAY | Cofactor biosynthesis; tetrahydrofolate biosynthesis; |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004156 | F:dihydropteroate synthase activity | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0046654 | P:tetrahydrofolate biosynthetic process | IEA | |
| GO:0046656 | P:folic acid biosynthetic process | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| P55A | resistant | PMID:21115799 | 51 |
| P55H | resistant | PMID:21115799 | 51 |
| P55L | resistant | PMID:21115799 | 51 |
| P55R | resistant | PMID:15603834 | 51 |
| P55S | resistant | PMID:15603834 | 51 |
| P55T | resistant | PMID:21115799 | 51 |
| R54G | resistant | PMID:21115799 | 50 |
| T53A | resistant | PMID:21115799 | 49 |
| T53I | resistant | PMID:21115799 | 49 |
| T53N | resistant | PMID:21115799 | 49 |
| T53P | resistant | PMID:21115799 | 49 |
| V48A | resistant | PMID:21115799 | 44 |
| V48F | resistant | PMID:21115799 | 44 |
| V48G | resistant | PMID:21115799 | 44 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| P55A | 55 |
| P55H | 55 |
| P55L | 55 |
| P55R | 55 |
| P55S | 55 |
| P55T | 55 |
| R54G | 54 |
| T53A | 53 |
| T53I | 53 |
| T53N | 53 |
| T53P | 53 |
| V48A | 48 |
| V48F | 48 |
| V48G | 48 |