EF-Tu - ARO:3003369-AAN82549.1
Model based on:
Entry features
| GENE | EF-Tu | |
|---|---|---|
| DESCRIPTION | P-43 | |
| ORGANISM | Escherichia coli CFT073 | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. | |
| UNIPROT | P0A6N2 | |
| NCBI | AAN82549.1 | |
| ARO term | ARO:3003369 | |
| Template | 4pc3 A | |
| RESISTANCE | elfamycin; pulvomycin |
Cross-references
| STRING | 199310.c4935 | |
|---|---|---|
| REFSEQ | WP_000031784.1; NC_004431.1 | |
| PFAM | PF00009 - GTP_EFTU; PF03143 - GTP_EFTU_D3; PF03144 - GTP_EFTU_D2 | |
| KEGG | ecc:c4111; ecc:c4935 | |
| EMBL | AE014075; AAN82549.1; ALT_INIT; AAN83363.1 | |
| BioCyc/EcoCyc/MetaCyc | ECOL199310:C4935-MONOMER | |
| NUCLEOTIDE BINDING | 136 139 GTP; 19 26 GTP; 81 85 GTP |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003746 | F:translation elongation factor activity | IEA | |
| GO:0003924 | F:GTPase activity | IEA | |
| GO:0005525 | F:GTP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005737 | C:cytoplasm | IEA | |
| GO:0005886 | C:plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| R231C | resistant | PMID:7957075 | 208 |
| R231V | resistant | PMID:7957075 | 208 |
| R234F | resistant | PMID:7957075 | 211 |
| R234S | resistant | PMID:7957075 | 211 |
| R334C | resistant | PMID:7957075 | 311 |
| T335A | resistant | PMID:7957075 | 312 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| R231C | 231 |
| R231V | 231 |
| R234F | 234 |
| R234S | 234 |
| R334C | 334 |
| T335A | 335 |