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PVAR3D
embC - ARO:3003327-AFN51819.1
Model based on:
Entry features
Model PirFile Alignment Superimposition Procheck MSA
GENE embC
ORGANISM Mycobacterium tuberculosis H37Rv
NCBI AFN51819.1
ARO term ARO:3003327
Template 3pty A
RESISTANCE ethambutol; polyamine
Cross-references
Mutation panel
Mutation Phenotype Reference Map mutation on Model
T270I,Y296H,G308D,G325S resistant PMID:PMID in progress (multiple) -
V981L resistant PMID:20427375 247
N394D resistant PMID:10639358 -
Y327N resistant PMID:PMID in progress (single) -
W326R resistant PMID:PMID in progress (single) -
G325S resistant PMID:PMID in progress (single) -
M310K resistant PMID:PMID in progress (single) -
Y309N resistant PMID:PMID in progress (single) -
G308D resistant PMID:PMID in progress (single) -
A307T resistant PMID:PMID in progress (single) -
V303G resistant PMID:PMID in progress (single) -
R302G resistant PMID:PMID in progress (single) -
M300R resistant PMID:PMID in progress (single) -
I297T resistant PMID:PMID in progress (single) -
I297L resistant PMID:PMID in progress (single) -
Y296S resistant PMID:PMID in progress (single) -
Y296H resistant PMID:PMID in progress (single) -
G288V resistant PMID:PMID in progress (single) -
G288W resistant PMID:PMID in progress (single) -
V287F resistant PMID:23995136 -
H285Y resistant PMID:19112008 -
A254G resistant PMID:16972132 -
L251R resistant PMID:19112008 -
A247P resistant PMID:16972132 -
L502P resistant PMID:23995136 -
Q491R resistant PMID:23995136 -
P398S resistant PMID:23995136 -
T270I resistant PMID:19112008 -
R738Q resistant PMID:10639358 4
I297L,W326R resistant PMID:PMID in progress (multiple) -
A244T,G288W,V303G resistant PMID:PMID in progress (multiple) -
T270I,I297T resistant PMID:PMID in progress (multiple) -
V287F,T309N resistant PMID:PMID in progress (multiple) -
L251R,A254G,T270I resistant PMID:PMID in progress (multiple) -
G288V,M310K,Y327N resistant PMID:PMID in progress (multiple) -
T270I,G288W,V303G resistant PMID:PMID in progress (multiple) -
G288W,V303G resistant PMID:PMID in progress (multiple) -
G272S,H285Y,M300R,A307T resistant PMID:PMID in progress (multiple) -
A247P,T270I,I297T resistant PMID:PMID in progress (multiple) -
Y296S,R302G resistant PMID:PMID in progress (multiple) -
V287F,Y309N resistant PMID:PMID in progress (multiple) -
A247P,I297L,W326R resistant PMID:PMID in progress (multiple) -
S244T resistant PMID:PMID in progress (single) -
Sequence
Multiple sequence alignment
MSA Mutation
Variant Position in MSA
T270I;Y296H;G308D;G325S 270;296;308;325
V981L 983
N394D 394
Y327N 327
W326R 326
G325S 325
M310K 310
Y309N 309
G308D 308
A307T 307
V303G 303
R302G 302
M300R 300
I297T 297
I297L 297
Y296S 296
Y296H 296
G288V 288
G288W 288
V287F 287
H285Y 285
A254G 254
L251R 251
A247P 247
L502P 502
Q491R 491
P398S 398
T270I 270
R738Q 738
I297L;W326R 297;326
A244T;G288W;V303G 244;288;303
T270I;I297T 270;297
V287F;T309N 287;309
L251R;A254G;T270I 251;254;270
G288V;M310K;Y327N 288;310;327
T270I;G288W;V303G 270;288;303
G288W;V303G 288;303
G272S;H285Y;M300R;A307T 272;285;300;307
A247P;T270I;I297T 247;270;297
Y296S;R302G 296;302
V287F;Y309N 287;309
A247P;I297L;W326R 247;297;326
S244T 244