mprF - ARO:3003319-ADJ67256
Model based on:
Entry features
| GENE | mprF | |
|---|---|---|
| DESCRIPTION | Lysylphosphatidylglycerol synthase | |
| ORGANISM | Staphylococcus aureus | |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus. | |
| UNIPROT | D9IFN8 | |
| NCBI | ADJ67256 | |
| ARO term | ARO:3003319 | |
| Template | 4v36 B | |
| RESISTANCE | daptomycin; peptide |
Cross-references
| PFAM | PF03706 - LPG_synthase_TM; PF09924 - DUF2156 | |
|---|---|---|
| EMBL | HM140975; ADJ67254.1; HM140977; ADJ67256.1 | |
| EC | 2.3.2.3 | |
| Catalytic activity | L-lysyl-tRNA(Lys) + phosphatidylglycerol = tRNA(Lys) + 3-O-L-lysyl-1-O-phosphatidylglycerol; ECO:0000256| RuleBase:RU363042 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0050071 | F:lysyltransferase activity | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006629 | P:lipid metabolic process | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005886 | C:plasma membrane | IEA | |
| GO:0016021 | C:integral component of membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| F57S | resistant | PMID:PMID in progress (single) | - |
| G61V | resistant | PMID:22238576 | - |
| I418N | resistant | PMID:PMID in progress (single) | - |
| I420N | resistant | PMID:22238576 | - |
| L341S | resistant | PMID:26055370 | - |
| L826F | resistant | PMID:16723576 PMID:22238576 | 316 |
| M347R | resistant | PMID:26055370 | - |
| P314L | resistant | PMID:16723576 PMID:26055370 | - |
| S295L | resistant | PMID:16723576 PMID:20498310 PMID:22238576 | - |
| S337L | resistant | PMID:22238576 | - |
| T345A | resistant | PMID:16723576 PMID:20498310 | - |
| T345I | resistant | PMID:16723576 PMID:22238576 | - |
| T345K | resistant | PMID:26055370 | - |
| T472K | resistant | PMID:26055370 | - |
| V351E | resistant | PMID:26055370 | - |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| F57S | 57 |
| G61V | 61 |
| I418N | 422 |
| I420N | 424 |
| L341S | 341 |
| L826F | 830 |
| M347R | 347 |
| P314L | 314 |
| S295L | 295 |
| S337L | 337 |
| T345A | 345 |
| T345I | 345 |
| T345K | 345 |
| T472K | 476 |
| V351E | 355 |