parE - ARO:3003314-BAA11086.1
Model based on:
Entry features
| GENE | parE | |
|---|---|---|
| DESCRIPTION | Topoisomerase IV subunit B | |
| ORGANISM | Staphylococcus aureus RN4220 | |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus. | |
| UNIPROT | Q2FYS5 | |
| NCBI | BAA11086.1 | |
| ARO term | ARO:3003314 | |
| Template | 4i3h B | |
| RESISTANCE | aminocoumarin; clorobiocin; coumermycin A1; novobiocin |
Cross-references
| STRING | 93061.SAOUHSC_01351 | |
|---|---|---|
| REFSEQ | WP_001548666.1; NZ_LS483365.1; YP_499879.1; NC_007795.1 | |
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|93061.5.peg.1237 | |
| KEGG | sao:SAOUHSC_01351 | |
| EMBL | CP000253; ABD30447.1; D67075; BAA11086.1 | |
| BioCyc/EcoCyc/MetaCyc | SAUR93061:G1G5Y-1262-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_00939 | |
| NUCLEOTIDE BINDING | 114 120 ATP |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IBA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IBA | |
| GO:0007059 | P:chromosome segregation | IBA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0009295 | C:nucleoid | IBA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| G78S | resistant | PMID:16127057 | 63 |
| R136G | resistant | PMID:16127057 | 121 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| G78S | 82 |
| R136G | 140 |