parC - ARO:3003309-WP_010891786.1
Model based on:
Entry features
| GENE | parC |
|---|---|
| ORGANISM | Ureaplasma parvum |
| TAXONOMY | Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma. |
| UNIPROT | A0A2C9DXX5 |
| NCBI | WP_010891786.1 |
| ARO term | ARO:3003309 |
| Template | 4juo A |
| RESISTANCE | ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| REFSEQ | WP_010891786.1; NC_010503.1 | |
|---|---|---|
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| KEGG | upa:UPA3_0486 | |
| EMBL | CP000942; ACA32704.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| SAAS:SAAS00993472 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| E87Q | resistant | PMID:27884651 | 81 |
| S83L | resistant | PMID:25645833 | 77 |
| S83W | resistant | PMID:25645833 | 77 |
| S84P | resistant | PMID:25645833 | 78 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available