gyrB - ARO:3003307-NP_462735.1
Model based on:
Entry features
| GENE | gyrB |
|---|---|
| ORGANISM | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Salmonella. |
| UNIPROT | P0A2I3 |
| NCBI | NP_462735.1 |
| ARO term | ARO:3003307 |
| Template | 4i3h A |
| RESISTANCE | aminocoumarin; ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin; quinolone |
Cross-references
| STRING | 99287.STM3835 | |
|---|---|---|
| REFSEQ | NP_462735.1; NC_003197.2; WP_000072047.1 | |
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|99287.12.peg.4062 | |
| KEGG | stm:STM3835 | |
| EMBL | AE006468; AAL22694.1; Y07916; CAA69221.1; Y08383; CAA69665.1; Z68167; CAA92320.1 | |
| BioCyc/EcoCyc/MetaCyc | SENT99287:G1FZD-3875-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01898 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IBA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IBA | |
| GO:0007059 | P:chromosome segregation | IBA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA | |
| GO:0009295 | C:nucleoid | IBA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| E466D | resistant | PMID:19104017 | 449 |
| S464F | resistant | PMID:NA | 447 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| E466D | 473 |
| S464F | 471 |