gyrB - ARO:3003305-WP_004025678.1
Model based on:
Entry features
| GENE | gyrB |
|---|---|
| ORGANISM | Ureaplasma urealyticum |
| TAXONOMY | Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma. |
| UNIPROT | B2NHA0 |
| NCBI | WP_004025678.1 |
| ARO term | ARO:3003305 |
| Template | 4i3h A |
| RESISTANCE | aminocoumarin; ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| REFSEQ | WP_004025678.1; NZ_AAZS01000005.1 | |
|---|---|---|
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|526347.8.peg.45 | |
| EMBL | AAZS01000005; EDU66810.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01898 ; ECO:0000256| SAAS:SAAS00924961 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| E502Q | resistant | PMID:27884651 | 480 |
| P462S | resistant | PMID:25645833 | 440 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| E502Q | 504 |
| P462S | 464 |