gyrB - ARO:3003304-CAC29513.1
Model based on:
Entry features
| GENE | gyrB |
|---|---|
| ORGANISM | Mycobacterium leprae TN |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium. |
| UNIPROT | Q59533 |
| NCBI | CAC29513.1 |
| ARO term | ARO:3003304 |
| Template | 3zkd F |
| RESISTANCE | aminocoumarin; ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| STRING | 272631.ML0005 | |
|---|---|---|
| REFSEQ | NP_301133.1; NC_002677.1; WP_010907458.1 | |
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|272631.5.peg.5 | |
| KEGG | mle:ML0005 | |
| EMBL | AL583917; CAC29513.1; Z70722; CAA94712.1; ALT_INIT | |
| BioCyc/EcoCyc/MetaCyc | MLEP272631:G1GT5-5-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01898 ; ECO:0000305| PubMed:17325221 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0034335 | F:DNA supercoiling activity | IDA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D464N | resistant | PMID:23071850 | - |
| E504V | resistant | PMID:23071850 | - |
| N502D | resistant | PMID:23071850 | - |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D464N | 521 |
| E504V | 561 |
| N502D | 559 |