gyrB - ARO:3003302-WP_005768149.1
Model based on:
Entry features
| GENE | gyrB |
|---|---|
| ORGANISM | Bartonella bacilliformis KC583 |
| TAXONOMY | Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;Bartonellaceae; Bartonella. |
| UNIPROT | A1UUE0 |
| NCBI | WP_005768149.1 |
| ARO term | ARO:3003302 |
| Template | 4i3h A |
| RESISTANCE | aminocoumarin; clorobiocin; coumermycin A1; novobiocin |
Cross-references
| STRING | 360095.BARBAKC583_1346 | |
|---|---|---|
| REFSEQ | WP_005768149.1; NC_008783.1 | |
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|360095.6.peg.1319 | |
| KEGG | bbk:BARBAKC583_1346 | |
| EMBL | CP000524; ABM44583.1 | |
| BioCyc/EcoCyc/MetaCyc | BBAC360095:G1G7W-1261-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01898 ; ECO:0000256| SAAS:SAAS00924961 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| G124S | resistant | PMID:9797224 | 99 |
| R184Q | resistant | PMID:9797224 | 159 |
| T214A | resistant | PMID:9797224 | 189 |
| T214I | resistant | PMID:9797224 | 189 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| G124S | 124 |
| R184Q | 194 |
| T214A | 224 |
| T214I | 224 |