gyrA - ARO:3003298-CAC29514.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Mycobacterium leprae TN |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium. |
| UNIPROT | Q57532 |
| NCBI | CAC29514.1 |
| ARO term | ARO:3003298 |
| Template | 4g3n A |
| RESISTANCE | ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; nybomycin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| STRING | 272631.ML0006 | |
|---|---|---|
| REFSEQ | WP_010907459.1; NC_002677.1 | |
| PTM | ||
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C; PF14528 - LAGLIDADG_3 | |
| EMBL | AL583917; CAC29514.1; ALT_FRAME; X87124; CAA60608.1; Z68206; CAA92430.1; Z70722; CAA94713.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01897 | |
| Active site | 130 130 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0004519 | F:endonuclease activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0034335 | F:DNA supercoiling activity | IDA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0016539 | P:intein-mediated protein splicing | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| A91T | resistant | PMID:15603834 | - |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A91T | 119 |