gyrA - ARO:3003297-AAL82403.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Bartonella bacilliformis |
| TAXONOMY | Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;Bartonellaceae; Bartonella. |
| UNIPROT | Q8RT68 |
| NCBI | AAL82403.1 |
| ARO term | ARO:3003297 |
| Template | 2y3p A |
| RESISTANCE | ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; nybomycin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| REFSEQ | WP_005766997.1; NZ_LQWW01000009.1 | |
|---|---|---|
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| EMBL | AF469609; AAL82403.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01897 ; ECO:0000256| SAAS:SAAS00993472 | |
| Active site | 130 130 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D90G | resistant | PMID:12499219 | 60 |
| D95N | resistant | PMID:12499219 | 65 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available