PBP2x - ARO:3003043-AFC91898.1
Model based on:
Entry features
| GENE | PBP2x |
|---|---|
| ORGANISM | Streptococcus pneumoniae |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;Streptococcus. |
| UNIPROT | H8ZYG5 |
| NCBI | AFC91898.1 |
| ARO term | ARO:3003043 |
| Template | 1qme A |
| RESISTANCE | amoxicillin; carbapenem; cephalosporin; cephamycin; monobactam; penam |
Cross-references
| PFAM | PF00905 - Transpeptidase; PF03717 - PBP_dimer; PF03793 - PASTA |
|---|---|
| EMBL | JN645704; AFC91896.1; JN645705; AFC91897.1; JN645706; AFC91898.1 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008658 | F:penicillin binding | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0016021 | C:integral component of membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| I371T | resistant | PMID:PMID in progress (single) | 301 |
| L546V | resistant | PMID:PMID in progress (single) | 476 |
| M339F | resistant | PMID:PMID in progress (single) | 269 |
| M400T | resistant | PMID:PMID in progress (single) | 330 |
| N514H | resistant | PMID:PMID in progress (single) | 444 |
| N605T | resistant | PMID:PMID in progress (single) | 535 |
| R384G | resistant | PMID:PMID in progress (single) | 314 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available