PBP1a - ARO:3003041-AFC91828.1
Model based on:
Entry features
| GENE | PBP1a |
|---|---|
| ORGANISM | Streptococcus pneumoniae |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;Streptococcus. |
| UNIPROT | H8ZYN4 |
| NCBI | AFC91828.1 |
| ARO term | ARO:3003041 |
| Template | 2zc6 B |
| RESISTANCE | amoxicillin; carbapenem; cephalosporin; cephamycin; monobactam; penam |
Cross-references
| PFAM | PF00905 - Transpeptidase; PF00912 - Transgly |
|---|---|
| EMBL | JN645775; AFC91827.1; JN645776; AFC91828.1 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008658 | F:penicillin binding | IEA | |
| GO:0016740 | F:transferase activity | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0016021 | C:integral component of membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| N609D | resistant | PMID:18394970 | 343 |
| S575T | resistant | PMID:18394970 | 309 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| N609D | 610 |
| S575T | 576 |