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PVAR3D
50S ribosomal protein L4 - P60723
Structure
Entry features
GENE 50S ribosomal protein L4
DESCRIPTION Large ribosomal subunit protein uL4
ORGANISM Escherichia coli (strain K12)
TAXONOMY Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia.
UNIPROT P60723
RESISTANCE erythromycin
Cross-references
STRING 316385.ECDH10B_3494
REFSEQ NP_417778.1; NC_000913.3; WP_000424395.1; NZ_LN832404.1
PFAM PF00573 - Ribosomal_L4
PATRIC fig|1411691.4.peg.3412
KEGG ecj:JW3281; eco:b3319
EMBL AP009048; BAE77972.1; U00096; AAC76344.1; U18997; AAA58116.1; X02613; CAA26461.1
BioCyc/EcoCyc/MetaCyc EcoCyc:EG10867-MONOMER; MetaCyc:EG10867-MONOMER
INTACT P60723
Drugbank DB01361 - Troleandomycin
MINT P60723

Gene Ontology
Molecular Function GO ID Term Evidence
GO:0003723 F:RNA binding IBA
GO:0019843 F:rRNA binding IEA
GO:0001217 F:bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding IMP
GO:0003735 F:structural constituent of ribosome IBA
GO:0060698 F:endoribonuclease inhibitor activity IDA
GO:0030371 F:translation repressor activity IDA
Biological Process GO ID Term Evidence
GO:0017148 P:negative regulation of translation IMP
GO:0046677 P:response to antibiotic IEA
GO:0006412 P:translation IEA
GO:0006353 P:DNA-templated transcription, termination IEA
GO:0045892 P:negative regulation of transcription, DNA-templated IMP
GO:0042255 P:ribosome assembly IMP
GO:0060702 P:negative regulation of endoribonuclease activity IDA
Cellular Component GO ID Term Evidence
GO:0042788 C:polysomal ribosome IMP
GO:0022625 C:cytosolic large ribosomal subunit IDA
GO:0015934 C:large ribosomal subunit IMP
GO:0032993 C:protein-DNA complex IMP
GO:0005829 C:cytosol IDA
Mutation panel
Mutation Phenotype Reference
K63E erythromycin PMID:4589347, PMID:7766155, PMID:7928988
Sequence
Multiple sequence alignment
MSA Mutation
Variant Position in MSA
K63E 63