DNA-directed RNA polymerase subunit beta - P60281
Structure
Entry features
| GENE | DNA-directed RNA polymerase subunit beta | |
|---|---|---|
| DESCRIPTION | RNA polymerase subunit beta | |
| ORGANISM | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycolicibacterium. | |
| UNIPROT | P60281 | |
| RESISTANCE | rifampicin |
Cross-references
| STRING | 246196.MSMEG_1367 |
|---|---|
| REFSEQ | WP_011727628.1; NZ_CP009494.1; YP_885753.1; NC_008596.1 |
| PFAM | PF10385 - RNA_pol_Rpb2_45; PF04560 - RNA_pol_Rpb2_7; PF04563 - RNA_pol_Rpb2_1; PF04561 - RNA_pol_Rpb2_2; PF04565 - RNA_pol_Rpb2_3; PF00562 - RNA_pol_Rpb2_6 |
| PATRIC | fig|246196.19.peg.1351 |
| KEGG | msb:LJ00_06815; msg:MSMEI_1328; msm:MSMEG_1367 |
| EMBL | AJ605718; CAE53837.1; CP000480; ABK70312.1; CP001663; AFP37801.1; ALT_INIT |
| BioCyc/EcoCyc/MetaCyc | MSME246196:G1H7P-1378-MONOMER |
| INTACT | P60281 |
| EC | 2.7.7.6 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003899 | F:DNA-directed 5'-3' RNA polymerase activity | IEA | |
| GO:0032549 | F:ribonucleoside binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006351 | P:transcription, DNA-templated | IEA | |
| GO:0046677 | P:response to antibiotic | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| D432V | resistant | PMID:NA |
| D432Y | resistant | PMID:NA |
| L449P | resistant | PMID:NA |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| L449P | 461 |