Penicillin-binding protein 2X - P59676
Structure
Entry features
| GENE | Penicillin-binding protein 2X |
|---|---|
| ORGANISM | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;Streptococcus. |
| UNIPROT | P59676 |
| RESISTANCE | cefotamine |
Cross-references
| STRING | 171101.spr0304 |
|---|---|
| REFSEQ | NP_357898.1; NC_003098.1; WP_000872267.1 |
| PFAM | PF00905 - Transpeptidase; PF03717 - PBP_dimer; PF03793 - PASTA |
| PATRIC | fig|171101.6.peg.341 |
| KEGG | spr:spr0304 |
| EMBL | AE007317; AAK99108.1; X16367; CAA34412.1 |
| BioCyc/EcoCyc/MetaCyc | SPNE171101:SPR0304-MONOMER |
| CHEMBL | CHEMBL1255138 |
| Active site | 337 337 Acyl-ester intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008658 | F:penicillin binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0007049 | P:cell cycle | IEA | |
| GO:0009252 | P:peptidoglycan biosynthetic process | IEA | |
| GO:0008360 | P:regulation of cell shape | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| GO:0071555 | P:cell wall organization | IEA | |
| GO:0051301 | P:cell division | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005886 | C:plasma membrane | IEA | |
| GO:0016021 | C:integral component of membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| M289T | resistant | PMID:NA |
| G597D | resistant | PMID:NA |
| G601V | resistant | PMID:NA |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available