folA - P43791
Model based on:
Cross-references
| STRING | 71421.HI0899 | |
|---|---|---|
| REFSEQ | NP_439060.1; NC_000907.1; WP_005648125.1 | |
| PFAM | PF00186 - DHFR_1 | |
| PATRIC | fig|71421.8.peg.941 | |
| KEGG | hin:HI0899 | |
| EMBL | L42023; AAC22559.1; X84205; CAA58991.1; X84206; CAA58992.1; X84207; CAA58993.1 | |
| BioCyc/EcoCyc/MetaCyc | HINF71421:G1GJ1-939-MONOMER | |
| EC | 1.5.1.3; | |
| PATHWAY | Cofactor biosynthesis; tetrahydrofolate biosynthesis; |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004146 | F:dihydrofolate reductase activity | IEA | |
| GO:0050661 | F:NADP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006545 | P:glycine biosynthetic process | IEA | |
| GO:0006730 | P:one-carbon metabolic process | IEA | |
| GO:0046654 | P:tetrahydrofolate biosynthetic process | IEA | |
| GO:0046677 | P:response to antibiotic | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| N13S |
(non-resistant) In strain: Isolate R1042 and Isolate R1047 |
PMID:NA | 12 |
| M21I |
(non-resistant) In strain: Isolate R1047 |
PMID:NA | 20 |
| P54A |
(non-resistant) In strain: Isolate R1047 |
PMID:NA | 53 |
| P56A |
(non-resistant) In strain: Isolate R906 |
PMID:NA | 55 |
| L67P |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 66 |
| E69K |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 68 |
| I74V |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 73 |
| D77N |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 76 |
| F79L |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 78 |
| I95L |
(non-resistant) In strain: Isolate R1047 |
PMID:NA | 94 |
| E135K |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 134 |
| R142H |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 141 |
| F154S |
(non-resistant) In strain: Isolate R1042 |
PMID:NA | 153 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available