fabI - P0AEK4
No structure available
Entry features
| GENE | fabI | |
|---|---|---|
| DESCRIPTION | NADH-dependent enoyl-ACP reductase | |
| ORGANISM | Escherichia coli (strain K12) | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. | |
| UNIPROT | P0AEK4 |
Cross-references
| STRING | 316385.ECDH10B_1405 | |
|---|---|---|
| REFSEQ | NP_415804.1; NC_000913.3; WP_000506490.1; NZ_LN832404.1 | |
| PATRIC | fig|1411691.4.peg.991 | |
| KEGG | ecj:JW1281; eco:b1288 | |
| EMBL | AP009048; BAA14841.1; M97219; AAA17755.1; U00096; AAC74370.1; X78733; CAA55381.1 | |
| BioCyc/EcoCyc/MetaCyc | EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER; MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER | |
| INTACT | P0AEK4 | |
| EC | 1.3.1.9; | |
| Drugbank | DB01691 - Indole Naphthyridinone; DB01865 - 3-(6-Aminopyridin-3-Yl)-N-Methyl-N-[(1-Methyl-1h-Indol-2-Yl)Methyl]Acrylamide; DB02379 - Beta-D-Glucose; DB03030 - 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole; DB03534 - 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide; DB08604 - Triclosan | |
| CHEMBL | CHEMBL1857 | |
| Active site | 146 146 Proton acceptor; 156 156 Proton acceptor | |
| PATHWAY | Cofactor biosynthesis; biotin biosynthesis. |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004318 | F:enoyl-[acyl-carrier-protein] reductase (NADH) activity | IDA | |
| GO:0016631 | F:enoyl-[acyl-carrier-protein] reductase activity | IEA | |
| GO:0042802 | F:identical protein binding | IDA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0008610 | P:lipid biosynthetic process | IDA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| GO:0051289 | P:protein homotetramerization | IDA | |
| GO:0030497 | P:fatty acid elongation | IDA | |
| GO:0009102 | P:biotin biosynthetic process | IMP | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005829 | C:cytosol | IDA | |
| GO:0016020 | C:membrane | HDA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| Y156F |
(non-resistant) No effect on substrate reduction |
PMID:NA |
| K201A |
(non-resistant) No effect on substrate reduction |
PMID:NA |
| R204A |
(non-resistant) No effect on substrate reduction |
PMID:NA |
| K205A |
(non-resistant) No effect on substrate reduction |
PMID:NA |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available