30S ribosomal protein S12 - P0A7S3
Structure
Entry features
| GENE | 30S ribosomal protein S12 | |
|---|---|---|
| DESCRIPTION | Small ribosomal subunit protein uS12 | |
| ORGANISM | Escherichia coli (strain K12) | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. | |
| UNIPROT | P0A7S3 | |
| RESISTANCE | streptomycin |
Cross-references
| STRING | 316385.ECDH10B_p2 | |
|---|---|---|
| REFSEQ | NP_417801.1; NC_000913.3; WP_000246815.1; NZ_CP011343.2 | |
| PFAM | PF00164 - Ribosom_S12_S23 | |
| PATRIC | fig|1411691.4.peg.3389 | |
| KEGG | ecj:JW3304; eco:b3342 | |
| EMBL | V00354; CAA23647.1; AP009048; BAE77949.1; U18997; AAA58139.1; J01688; AAA50988.1; V00355; CAA23648.1; AF312716; AAG30936.1; AF312717; AAG30937.1; U00096; AAC76367.1 | |
| BioCyc/EcoCyc/MetaCyc | EcoCyc:EG10911-MONOMER; MetaCyc:EG10911-MONOMER | |
| INTACT | P0A7S3 | |
| Drugbank | DB00452 - Framycetin; DB00479 - Amikacin; DB00560 - Tigecycline; DB00684 - Tobramycin; DB00798 - Gentamicin; DB00919 - Spectinomycin; DB00955 - Netilmicin; DB00994 - Neomycin; DB01082 - Streptomycin; DB01172 - Kanamycin; DB03615 - Ribostamycin; DB04729 - GENTAMICIN C1A; DB06696 - Arbekacin |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0000049 | F:tRNA binding | IEA | |
| GO:0003735 | F:structural constituent of ribosome | IDA | |
| GO:0019843 | F:rRNA binding | IDA | |
| GO:0034336 | F:misfolded RNA binding | IDA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0046677 | P:response to antibiotic | IEA | |
| GO:0034337 | P:RNA folding | IDA | |
| GO:0006412 | P:translation | IMP | |
| GO:0033120 | P:positive regulation of RNA splicing | IDA | |
| GO:0000372 | P:Group I intron splicing | IDA | |
| GO:1990145 | P:maintenance of translational fidelity | IMP | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005829 | C:cytosol | IDA | |
| GO:0022627 | C:cytosolic small ribosomal subunit | IDA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| K43R | resistant | PMID:NA |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| K43R | 43 |