Oxygen-insensitive NADPH nitroreductase - O25608
Structure
Entry features
| GENE | Oxygen-insensitive NADPH nitroreductase |
|---|---|
| ORGANISM | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
| TAXONOMY | Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;Helicobacteraceae; Helicobacter. |
| UNIPROT | O25608 |
| RESISTANCE | metronidazole |
Cross-references
| STRING | 85962.HP0954 | |
|---|---|---|
| REFSEQ | NP_207746.1; NC_000915.1; WP_000670110.1; NC_018939.1 | |
| PFAM | PF00881 - Nitroreductase | |
| PATRIC | fig|85962.47.peg.1022 | |
| KEGG | heo:C694_04915; hpy:HP0954 | |
| EMBL | AF315502; AAK17125.1; AE000511; AAD07997.1; AF315501; AAK17124.1; AF012552; AAC46349.1; AF316109; AAK19260.1 | |
| BioCyc/EcoCyc/MetaCyc | HPY:HP0954-MONOMER | |
| INTACT | O25608 | |
| EC | 1.-.-.-; | |
| Drugbank | DB00916 - Metronidazole | |
| MINT | O25608 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0016491 | F:oxidoreductase activity | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0046677 | P:response to antibiotic | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| N14K | resistant | PMID:NA |
| T31E | resistant | PMID:NA |
| I36V | resistant | PMID:NA |
| M56I | resistant | PMID:NA |
| D59N | resistant | PMID:NA |
| C19Y | resistant | PMID:NA |
| T49K | resistant | PMID:NA |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| N14K | 14 |
| T31E | 31 |
| I36V | 36 |
| M56I | 56 |
| D59N | 59 |
| C19Y | 19 |
| T49K | 49 |