PBP3 - ARO:3004446-NP_439290
Model based on:
Entry features
| GENE | PBP3 | |
|---|---|---|
| DESCRIPTION | Penicillin-binding protein 3 | |
| ORGANISM | Haemophilus influenzae Rd KW20 | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;Pasteurellaceae; Haemophilus. | |
| UNIPROT | P45059 | |
| NCBI | NP_439290 | |
| ARO term | ARO:3004446 | |
| Template | 5DF8 B | |
| RESISTANCE | carbapenem; cephalosporin; cephamycin; monobactam; penam |
Cross-references
| STRING | 71421.HI1132 | |
|---|---|---|
| REFSEQ | NP_439290.1; NC_000907.1; WP_005693446.1 | |
| PFAM | PF00905 - Transpeptidase; PF03717 - PBP_dimer | |
| PATRIC | fig|71421.8.peg.1182 | |
| KEGG | hin:HI1132 | |
| EMBL | L42023; AAC22787.1 | |
| BioCyc/EcoCyc/MetaCyc | HINF71421:G1GJ1-1165-MONOMER | |
| EC | 3.4.16.4 | |
| Drugbank | DB00303 - Ertapenem | |
| Catalytic activity | Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|- D-Ala; Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine| Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine | |
| Active site | 327 327 Acyl-ester intermediate | |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_02080}. |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008658 | F:penicillin binding | IEA | |
| GO:0008955 | F:peptidoglycan glycosyltransferase activity | IEA | |
| GO:0009002 | F:serine-type D-Ala-D-Ala carboxypeptidase activity | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0008360 | P:regulation of cell shape | IEA | |
| GO:0009252 | P:peptidoglycan biosynthetic process | IEA | |
| GO:0043093 | P:FtsZ-dependent cytokinesis | IEA | |
| GO:0071555 | P:cell wall organization | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005887 | C:integral component of plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D350N | resistant | PMID:PMID in progress (single) | 265 |
| L389F | resistant | PMID:PMID in progress (single) | 304 |
| S357N | resistant | PMID:PMID in progress (single) | 272 |
| S385T | resistant | PMID:PMID in progress (single) | 300 |
| V562L | resistant | PMID:PMID in progress (single) | 477 |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available