folC - ARO:3004157-NP_216963.1
Structure
Entry features
| GENE | folC | |
|---|---|---|
| DESCRIPTION | Folylpoly-gamma-glutamate synthetase | |
| ORGANISM | Mycobacterium tuberculosis H37Rv | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. | |
| UNIPROT | I6Y0R5 | |
| NCBI | NP_216963.1 | |
| ARO term | ARO:3004157 | |
| RESISTANCE | aminosalicylate; para-aminosalicylic acid |
Cross-references
| STRING | 83332.Rv2447c | |
|---|---|---|
| REFSEQ | NP_216963.1; NC_000962.3; WP_003899324.1; NZ_KK339370.1 | |
| PFAM | PF02875 - Mur_ligase_C; PF08245 - Mur_ligase_M | |
| PATRIC | fig|83332.111.peg.2739 | |
| KEGG | mtu:Rv2447c; mtv:RVBD_2447c | |
| EMBL | AL123456; CCP45240.1; CP009480; AIR15214.1 | |
| EC | 6.3.2.12; 6.3.2.17 | |
| Catalytic activity | ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate; ECO:0000269| PubMed:23118010 ; ECO:0000269| PubMed:24366731 ATP + tetrahydropteroyl-(gamma-Glu)(n) + L- glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1); ECO:0000250| UniProtKB:P08192 | |
| PATHWAY | Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. {ECO:0000250|UniProtKB:P08192}. | |
| NUCLEOTIDE BINDING | 351 354 ATP; 74 77 ATP |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004326 | F:tetrahydrofolylpolyglutamate synthase activity | IBA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0008841 | F:dihydrofolate synthase activity | IBA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0046654 | P:tetrahydrofolate biosynthetic process | IEA | |
| GO:0046656 | P:folic acid biosynthetic process | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005737 | C:cytoplasm | IBA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| A420V | para-aminosalicylic acid | PMID:PMID in progress (single) |
| E153A | para-aminosalicylic acid | PMID:24366731 PMID:PMID in progress (single) |
| E153G | para-aminosalicylic acid | PMID:24366731 PMID:PMID in progress (single) |
| E40A | para-aminosalicylic acid | PMID:23779105 |
| E40G | para-aminosalicylic acid | PMID:24366731 PMID:PMID in progress (single) |
| E40Q | para-aminosalicylic acid | PMID:PMID in progress (single) |
| F152S | para-aminosalicylic acid | PMID:24366731 |
| I43A | para-aminosalicylic acid | PMID:24366731 PMID:PMID in progress (single) |
| I43S | para-aminosalicylic acid | PMID:PMID in progress (single) |
| I43T | para-aminosalicylic acid | PMID:24366731 PMID:PMID in progress (single) |
| L56V | para-aminosalicylic acid | PMID:PMID in progress (single) |
| N73S | para-aminosalicylic acid | PMID:24366731 |
| R49P | para-aminosalicylic acid | PMID:PMID in progress (single) |
| R49W | para-aminosalicylic acid | PMID:PMID in progress (single) |
| R91W | para-aminosalicylic acid | PMID:PMID in progress (single) |
| S150C | para-aminosalicylic acid | PMID:PMID in progress (single) |
| S150G | para-aminosalicylic acid | PMID:24366731 PMID:PMID in progress (single) |
| T20P | para-aminosalicylic acid | PMID:PMID in progress (single) |
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available