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PVAR3D
fabI - ARO:3004045-NP_415804.1
Structure
Entry features
GENE fabI
DESCRIPTION NADH-dependent enoyl-ACP reductase
ORGANISM Escherichia coli str. K-12 substr. MG1655
TAXONOMY Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia.
UNIPROT P0AEK4
NCBI NP_415804.1
ARO term ARO:3004045
RESISTANCE isoniazid; triclosan; diazaborine
Cross-references
STRING 316385.ECDH10B_1405
REFSEQ NP_415804.1; NC_000913.3; WP_000506490.1; NZ_LN832404.1
PATRIC fig|1411691.4.peg.991
KEGG ecj:JW1281; eco:b1288
EMBL AP009048; BAA14841.1; M97219; AAA17755.1; U00096; AAC74370.1; X78733; CAA55381.1
BioCyc/EcoCyc/MetaCyc EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER; MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER
INTACT P0AEK4
EC 1.3.1.9;
Drugbank DB01691 - Indole Naphthyridinone; DB01865 - 3-(6-Aminopyridin-3-Yl)-N-Methyl-N-[(1-Methyl-1h-Indol-2-Yl)Methyl]Acrylamide; DB02379 - Beta-D-Glucose; DB03030 - 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole; DB03534 - 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide; DB08604 - Triclosan
CHEMBL CHEMBL1857
Catalytic activity An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH; ECO:0000269| PubMed:8119879
Active site 146 146 Proton acceptor; 156 156 Proton acceptor
PATHWAY Cofactor biosynthesis; biotin biosynthesis.
NUCLEOTIDE BINDING 19 20 NAD; 192 196 NAD; 64 65 NAD

Gene Ontology
Molecular Function GO ID Term Evidence
GO:0004318 F:enoyl-[acyl-carrier-protein] reductase (NADH) activity IDA
GO:0016631 F:enoyl-[acyl-carrier-protein] reductase activity IEA
GO:0042802 F:identical protein binding IDA
Biological Process GO ID Term Evidence
GO:0008610 P:lipid biosynthetic process IDA
GO:0009102 P:biotin biosynthetic process IMP
GO:0030497 P:fatty acid elongation IDA
GO:0046677 P:response to antibiotic IEA
GO:0051289 P:protein homotetramerization IDA
Cellular Component GO ID Term Evidence
GO:0005829 C:cytosol IDA
GO:0016020 C:membrane HDA
Mutation panel
Mutation Phenotype Reference
F203A resistant PMID:PMID in progress (single)
F203C resistant PMID:PMID in progress (single)
F203L resistant PMID:PMID in progress (single)
F203V resistant PMID:PMID in progress (single)
G93A resistant PMID:PMID in progress (single)
G93S resistant PMID:PMID in progress (single)
G93V resistant PMID:PMID in progress (single)
M159T resistant PMID:PMID in progress (single)
Sequence
Multiple sequence alignment
MSA Mutation
Variant Position in MSA
F203A 206
F203C 206
F203L 206
F203V 206
G93A 95
G93S 95
G93V 95
M159T 162