gyrA - ARO:3003940-NP_708120.1
Structure
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Shigella flexneri 2a str. 301 |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Shigella. |
| UNIPROT | P0AES5 |
| NCBI | NP_708120.1 |
| ARO term | ARO:3003940 |
| RESISTANCE | fluoroquinolone; nalidixic acid; norfloxacin; nybomycin |
Cross-references
| REFSEQ | NP_708120.1; NC_004337.2; WP_001281242.1; NZ_QDEA01000022.1 | |
|---|---|---|
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|198214.7.peg.2769 | |
| KEGG | sfl:SF2311; sfx:S2444 | |
| EMBL | AE005674; AAN43827.1; AE014073; AAP17645.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01897 | |
| Active site | 122 122 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| H80P | resistant | PMID:27620866 |
| N57K | resistant | PMID:27620866 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| H80P | 81 |
| N57K | 58 |