gyrA - ARO:3003789-YP_002344422.1
Model based on:
Entry features
| GENE | gyrA |
|---|---|
| ORGANISM | Campylobacter jejuni subsp. jejuni NCTC 11168 |
| TAXONOMY | Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;Campylobacteraceae; Campylobacter. |
| UNIPROT | Q03470 |
| NCBI | YP_002344422.1 |
| ARO term | ARO:3003789 |
| Template | 4DDQ B |
| RESISTANCE | ciprofloxacin; fluoroquinolone; nybomycin; nalidixic acid and ciprofloxacin |
Cross-references
| STRING | 192222.Cj1027c | |
|---|---|---|
| REFSEQ | WP_002857904.1; NC_002163.1; YP_002344422.1 | |
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
| PATRIC | fig|192222.6.peg.1009 | |
| KEGG | cje:Cj1027c | |
| EMBL | AL111168; CAL35145.1; L04566; AAA23028.1 | |
| BioCyc/EcoCyc/MetaCyc | CJEJ192222:G1G1F-987-MONOMER | |
| INTACT | Q03470 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_01897 | |
| Active site | 125 125 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006261 | P:DNA-dependent DNA replication | IEA | |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| A70T | resistant | PMID:NA | 36 |
| D90N | resistant | PMID:NA | 56 |
| T86I | resistant | PMID:26658311 | 52 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A70T | 71 |
| D90N | 91 |
| T86I | 87 |