murA - ARO:3003777-NP_212606.2
Model based on:
Entry features
| GENE | murA | |
|---|---|---|
| DESCRIPTION | Enoylpyruvate transferase | |
| ORGANISM | Borrelia burgdorferi B31 | |
| TAXONOMY | Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella. | |
| UNIPROT | O51428 | |
| NCBI | NP_212606.2 | |
| ARO term | ARO:3003777 | |
| Template | 1UAE A | |
| RESISTANCE | fosfomycin |
Cross-references
| STRING | 224326.BB_0472 | |
|---|---|---|
| REFSEQ | NP_212606.2; NC_001318.1; WP_002656466.1 | |
| PFAM | PF00275 - EPSP_synthase | |
| PATRIC | fig|224326.49.peg.864 | |
| KEGG | bbu:BB_0472 | |
| EMBL | AE000783; AAC66824.2 | |
| EC | 2.5.1.7 | |
| Catalytic activity | Phosphoenolpyruvate + UDP-N-acetyl-alpha-D- glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha- D-glucosamine; ECO:0000255| HAMAP-Rule:MF_00111 | |
| Active site | 116 116 Proton donor | |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00111}. |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008760 | F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0007049 | P:cell cycle | IEA | |
| GO:0008360 | P:regulation of cell shape | IEA | |
| GO:0009252 | P:peptidoglycan biosynthetic process | IEA | |
| GO:0019277 | P:UDP-N-acetylgalactosamine biosynthetic process | IEA | |
| GO:0051301 | P:cell division | IEA | |
| GO:0071555 | P:cell wall organization | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005829 | C:cytosol | IDA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D116C | resistant | PMID:21294548 | 116 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D116C | 116 |