murA - ARO:3003776-CAG41169.1
Model based on:
Entry features
| GENE | murA | |
|---|---|---|
| DESCRIPTION | Enoylpyruvate transferase 1 | |
| ORGANISM | Staphylococcus aureus subsp. aureus MRSA252 | |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus. | |
| UNIPROT | Q6GEX5 | |
| NCBI | CAG41169.1 | |
| ARO term | ARO:3003776 | |
| Template | 3SG1 D | |
| RESISTANCE | fosfomycin |
Cross-references
| REFSEQ | WP_000358009.1; NC_002952.2 | |
|---|---|---|
| PFAM | PF00275 - EPSP_synthase | |
| KEGG | sar:SAR2188 | |
| EMBL | BX571856; CAG41169.1 | |
| EC | 2.5.1.7 | |
| Catalytic activity | Phosphoenolpyruvate + UDP-N-acetyl-alpha-D- glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha- D-glucosamine; ECO:0000255| HAMAP-Rule:MF_00111 | |
| Active site | 119 119 Proton donor | |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00111}. |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008760 | F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0007049 | P:cell cycle | IEA | |
| GO:0008360 | P:regulation of cell shape | IEA | |
| GO:0009252 | P:peptidoglycan biosynthetic process | IEA | |
| GO:0019277 | P:UDP-N-acetylgalactosamine biosynthetic process | IEA | |
| GO:0051301 | P:cell division | IEA | |
| GO:0071555 | P:cell wall organization | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| D278E | resistant | PMID:26793179 | 278 |
| E291D | resistant | PMID:26793179 | 291 |
| G257D | resistant | PMID:26793179 | 257 |
| Q362R | resistant | PMID:26793179 | 362 |
| T396N | resistant | PMID:26793179 | 396 |
| V65L | resistant | PMID:26793179 | 65 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D278E | 278 |
| E291D | 291 |
| G257D | 257 |
| Q362R | 362 |
| T396N | 396 |
| V65L | 65 |