ileS - ARO:3003729-CAA52296.1
Structure
Entry features
| GENE | ileS | |
|---|---|---|
| DESCRIPTION | Isoleucyl-tRNA synthetase | |
| ORGANISM | Staphylococcus aureus | |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;Staphylococcus. | |
| UNIPROT | P41972 | |
| NCBI | CAA52296.1 | |
| ARO term | ARO:3003729 | |
| RESISTANCE | mupirocin |
Cross-references
| REFSEQ | WP_000384706.1; NZ_QAJY01000010.1 | |
|---|---|---|
| PFAM | PF00133 - tRNA-synt_1; PF06827 - zf-FPG_IleRS; PF08264 - Anticodon_1 | |
| EMBL | X74219; CAA52296.1 | |
| EC | 6.1.1.5; | |
| Drugbank | DB00410 - Mupirocin | |
| CHEMBL | CHEMBL1982 | |
| Catalytic activity | ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile); | |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0000049 | F:tRNA binding | IEA | |
| GO:0002161 | F:aminoacyl-tRNA editing activity | IEA | |
| GO:0004822 | F:isoleucine-tRNA ligase activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| GO:0008270 | F:zinc ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006428 | P:isoleucyl-tRNA aminoacylation | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005737 | C:cytoplasm | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| V588F | resistant | PMID:11796355 |
| V631F | resistant | PMID:11796355 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| V588F | 588 |
| V631F | 631 |