pncA - ARO:3003394-CCP44816.1
Structure
Entry features
| GENE | pncA | |
|---|---|---|
| DESCRIPTION | Nicotinamidase | |
| ORGANISM | Mycobacterium tuberculosis H37Rv | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. | |
| UNIPROT | I6XD65 | |
| NCBI | CCP44816.1 | |
| ARO term | ARO:3003394 | |
| RESISTANCE | pyrazinamide |
Cross-references
| STRING | 83332.Rv2043c | |
|---|---|---|
| REFSEQ | NP_216559.1; NC_000962.3; WP_003410243.1; NZ_KK339370.1 | |
| PFAM | PF00857 - Isochorismatase | |
| PATRIC | fig|83332.111.peg.2278 | |
| KEGG | mtu:Rv2043c; mtv:RVBD_2043c | |
| EMBL | AL123456; CCP44816.1; CP009480; AIR14792.1 | |
| EC | 3.5.1.-; 3.5.1.19 | |
| Catalytic activity | Nicotinamide + H(2)O = nicotinate + NH(3); ECO:0000269| PubMed:18201201 Pyrazinamide + H(2)O = pyrazine-2-carboxylate + NH(3); ECO:0000269| PubMed:18201201 | |
| Active site | 8 8 Proton acceptor; 96 96 {ECO:0000305|PubMed:21283666}; 138 138 Nucleophile | |
| PATHWAY | Cofactor biosynthesis; nicotinate biosynthesis; |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0008198 | F:ferrous iron binding | IDA | |
| GO:0008936 | F:nicotinamidase activity | IDA | |
| GO:0030145 | F:manganese ion binding | IDA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006769 | P:nicotinamide metabolic process | IDA | |
| GO:0017144 | P:drug metabolic process | IDA | |
| GO:0019363 | P:pyridine nucleotide biosynthetic process | IEA | |
| GO:0046677 | P:response to antibiotic | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005737 | C:cytoplasm | IBA |
Mutation panel
Sequence
Multiple sequence alignment Not Available
MSA Mutation Not Available