inhA - ARO:3003393-CCP44244.1
Structure
Entry features
| GENE | inhA | |
|---|---|---|
| DESCRIPTION | FAS-II enoyl-ACP reductase | |
| ORGANISM | Mycobacterium tuberculosis H37Rv | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. | |
| UNIPROT | P9WGR1 | |
| NCBI | CCP44244.1 | |
| ARO term | ARO:3003393 | |
| RESISTANCE | isoniazid; triclosan; pyridomycin |
Cross-references
| STRING | 83332.Rv1484 | |
|---|---|---|
| REFSEQ | NP_216000.1; NC_000962.3; WP_003407553.1; NZ_KK339370.1 | |
| PTM | ||
| KEGG | mtu:Rv1484 | |
| EMBL | AL123456; CCP44244.1; AY155363; AAN75060.1; U02492; AAC43210.1 | |
| BioCyc/EcoCyc/MetaCyc | MetaCyc:G185E-5668-MONOMER | |
| EC | 1.3.1.9 | |
| CHEMBL | CHEMBL1849 | |
| Catalytic activity | An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH; ECO:0000269| PubMed:10521269 ; ECO:0000269| PubMed:20864541 ; ECO:0000269| PubMed:21143326 ; ECO:0000269| PubMed:22987724 ; ECO:0000269| PubMed:7599116 | |
| PATHWAY | Lipid metabolism; mycolic acid biosynthesis. {ECO:0000303|PubMed:25227413}. | |
| NUCLEOTIDE BINDING | 20 21 NAD; 64 65 NAD; 95 96 NAD |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004318 | F:enoyl-[acyl-carrier-protein] reductase (NADH) activity | IDA | |
| GO:0005504 | F:fatty acid binding | IDA | |
| GO:0016631 | F:enoyl-[acyl-carrier-protein] reductase activity | IEA | |
| GO:0070403 | F:NAD+ binding | IDA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0030497 | P:fatty acid elongation | IMP | |
| GO:0046677 | P:response to antibiotic | IEA | |
| GO:0071768 | P:mycolic acid biosynthetic process | IDA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005618 | C:cell wall | IDA | |
| GO:0005886 | C:plasma membrane | IDA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| D148G | resistant | PMID:NA |
| I16T | resistant | PMID:9728546 |
| I194T | resistant | PMID:23539241 |
| I21T | resistant | PMID:9728546 |
| I21V | resistant | PMID:9728546 |
| I47T | resistant | PMID:9728546 |
| I95P | resistant | PMID:9728546 |
| S94A | resistant | PMID:9728546 |
| V78A | resistant | PMID:9728546 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D148G | 148 |
| I16T | 16 |
| I194T | 194 |
| I21T | 21 |
| I21V | 21 |
| I47T | 47 |
| I95P | 95 |
| S94A | 94 |
| V78A | 78 |