katG - ARO:3003392-NP_216424.1
Structure
Entry features
| GENE | katG | |
|---|---|---|
| DESCRIPTION | Peroxidase/catalase | |
| ORGANISM | Mycobacterium tuberculosis H37Rv | |
| TAXONOMY | Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;Mycobacterium; Mycobacterium tuberculosis complex. | |
| UNIPROT | A0A0N9DQS3 | |
| NCBI | NP_216424.1 | |
| ARO term | ARO:3003392 | |
| RESISTANCE | isoniazid |
Cross-references
| REFSEQ | NP_216424.1; NC_000962.3; WP_003899075.1; NZ_KK339370.1 | |
|---|---|---|
| PTM | ||
| PFAM | PF00141 - peroxidase | |
| KEGG | mtu:Rv1908c | |
| EMBL | CP009480; AIR14653.1 | |
| EC | 1.11.1.21 | |
| Catalytic activity | 2 H(2)O(2) = O(2) + 2 H(2)O; ECO:0000256| HAMAP-Rule:MF_01961 ; ECO:0000256| RuleBase:RU003451 ; ECO:0000256| SAAS:SAAS00704184 Donor + H(2)O(2) = oxidized donor + 2 H(2)O; ECO:0000256| HAMAP-Rule:MF_01961 ; ECO:0000256| RuleBase:RU003451 ; ECO:0000256| SAAS:SAAS00704189 | |
| Active site | 108 108 Proton acceptor |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0004096 | F:catalase activity | IEA | |
| GO:0020037 | F:heme binding | IEA | |
| GO:0046872 | F:metal ion binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006979 | P:response to oxidative stress | IEA | |
| GO:0042744 | P:hydrogen peroxide catabolic process | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| G269D | resistant | PMID:26251830 |
| M255Y | resistant | PMID:20054829 |
| T306P | resistant | PMID:26251830 |
| R385W | resistant | PMID:26251830 |
| M255I | resistant | PMID:20054829 |
| D387G | resistant | PMID:26251830 |
| T394M | resistant | PMID:26251830 |
| L101P | resistant | PMID:23744165 |
| L472I | resistant | PMID:28904673 |
| L472Q | resistant | PMID:28904673 |
| L472K | resistant | PMID:28904673 |
| Q471H | resistant | PMID:28904673 |
| Q471Y | resistant | PMID:28904673 |
| Q439P | resistant | PMID:26251830 |
| F483L | resistant | PMID:26251830 |
| A541D | resistant | PMID:26251830 |
| L436G | resistant | PMID:28904673 |
| T435R | resistant | PMID:28904673 |
| P131R | resistant | PMID:23744165 |
| W107F | resistant | PMID:20054829 |
| W91R | resistant | PMID:23744165 |
| R463L | resistant | PMID:23744165 PMID:20054829 PMID:8585728 |
| S315T | resistant | PMID:23744165 PMID:20054829 PMID:20211896 PMID:8585728 |
| G32D | resistant | PMID:26251830 |
| V47E | resistant | PMID:26251830 |
| M255C | resistant | PMID:20054829 |
| D194G | resistant | PMID:26251830 |
| A256T | resistant | PMID:26251830 |
| T667P | resistant | PMID:26251830 |
| M624V | resistant | PMID:26251830 |
| A717P | resistant | PMID:8585728 |
| I335T | resistant | PMID:8585728 |
| Q127P | resistant | PMID:24184004 |
| Q352E | resistant | PMID:24184004 |
| Y98C | resistant | PMID:24184004 |
| A379T | resistant | PMID:24184004 |
| G269R | resistant | PMID:24184004 |
| A431V | resistant | PMID:24626681 |
| S383P | resistant | PMID:20211896 |
| P232S | resistant | PMID:20211896 |
| S17T | resistant | PMID:25093512 |
| A93T | resistant | PMID:25093512 |
| N133T | resistant | PMID:20211896 |
| D36E | resistant | PMID:24468786 |
| A110V | resistant | PMID:26157154 |
| A139V | resistant | PMID:26092854 |
| G300W | resistant | PMID:26092854 |
| H276M | resistant | PMID:21330112 |
| Q295H | resistant | PMID:21330112 |
| S17N | resistant | PMID:7798673 |
| G19D | resistant | PMID:7798673 |
| Q224E | resistant | PMID:7798673 |
| A243S | resistant | PMID:7798673 |
| A550D | resistant | PMID:7798673 |
| P2S | resistant | PMID:7798673 |
| S140N | resistant | PMID:7798673 |
| G279D | resistant | PMID:14638486 |
| G285D | resistant | PMID:18508939 |
| G316D | resistant | PMID:16870753 |
| S457I | resistant | PMID:19520719 |
| G593D | resistant | PMID:10645439 |
| Q127E | resistant | PMID:20211896 |
| D735N | resistant | PMID:20054829 |
| G629S | resistant | PMID:20054829 PMID:8585728 |
| L587M | resistant | PMID:20054829 |
| S315R | resistant | PMID:20054829 PMID:20211896 |
| S315G | resistant | PMID:20054829 |
| A350S | resistant | PMID:20054829 PMID:8585728 |
| Y337C | resistant | PMID:20054829 |
| W328G | resistant | PMID:20054829 |
| T275P | resistant | PMID:20054829 |
| T262R | resistant | PMID:20054829 PMID:8585728 |
| S315I | resistant | PMID:23744165 PMID:20054829 |
| M126I | resistant | PMID:23744165 |
| S315N | resistant | PMID:23744165 PMID:20054829 |
| H97R | resistant | PMID:20211896 |
| N596S, Y597H | resistant | PMID:26251830 |
| V473F | resistant | PMID:28904673 |
| V473W | resistant | PMID:28904673 |
| V473Y | resistant | PMID:28904673 |
| V473G | resistant | PMID:28904673 |
| V473N | resistant | PMID:28904673 |
| V473S | resistant | PMID:28904673 |
| V473M | resistant | PMID:28904673 |
| V473R | resistant | PMID:28904673 |
| V473K | resistant | PMID:28904673 |
| V473I | resistant | PMID:28904673 |
| V473D | resistant | PMID:28904673 |
| A234G | resistant | PMID:23744165 |
| V68G | resistant | PMID:23744165 |
| W300G | resistant | PMID:20054829 |
| Y229F | resistant | PMID:20054829 |
| N138S | resistant | PMID:20054829 |
| N138D | resistant | PMID:20054829 |
| H108Q | resistant | PMID:20054829 PMID:8585728 |
| H108E | resistant | PMID:20054829 |
| W107R | resistant | PMID:20054829 |
| R104L | resistant | PMID:20054829 |
| D63E | resistant | PMID:20054829 PMID:8585728 |
| D194Y | resistant | PMID:23744165 |
| P131Q | resistant | PMID:23744165 |
| S303L | resistant | PMID:28904673 |
| S303C | resistant | PMID:28904673 |
| D311N | resistant | PMID:28904673 |
| D311S | resistant | PMID:28904673 |
| L427I | resistant | PMID:28904673 |
| L430V | resistant | PMID:28904673 |
| R128Q | resistant | PMID:23744165 |
| R489S | resistant | PMID:20211896 |
| M420T | resistant | PMID:20211896 |
| D387H | resistant | PMID:20211896 |
| G123E | resistant | PMID:20211896 |
| G299S | resistant | PMID:20211896 |
| D419H | resistant | PMID:20211896 |
| M176T | resistant | PMID:20211896 |
| R632C | resistant | PMID:20211896 |
| D542H | resistant | PMID:20211896 |
| Y64S | resistant | PMID:26251830 |
| Y95C | resistant | PMID:26251830 |
| P131T | resistant | PMID:26251830 |
| A139P | resistant | PMID:26251830 |
| D142G | resistant | PMID:26251830 |
| R418L | resistant | PMID:20054829 |
| W328F | resistant | PMID:20054829 |
| W321F | resistant | PMID:20054829 |
| T275V | resistant | PMID:20054829 |
| A162V | resistant | PMID:26251830 |
| P501A | resistant | PMID:NA |
| Q525P | resistant | PMID:NA |
| L587P | resistant | PMID:NA |
| S700P | resistant | PMID:NA |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| G269D | 287 |
| M255Y | 273 |
| T306P | 325 |
| R385W | 405 |
| M255I | 273 |
| D387G | 407 |
| T394M | 414 |
| L101P | 113 |
| L472I | 492 |
| L472Q | 492 |
| L472K | 492 |
| Q471H | 491 |
| Q471Y | 491 |
| Q439P | 459 |
| F483L | 503 |
| A541D | 561 |
| L436G | 456 |
| T435R | 455 |
| P131R | 143 |
| W107F | 119 |
| W91R | 103 |
| R463L | 483 |
| S315T | 334 |
| G32D | 43 |
| V47E | 59 |
| M255C | 273 |
| D194G | 206 |
| A256T | 274 |
| T667P | 687 |
| M624V | 644 |
| A717P | 738 |
| I335T | 354 |
| Q127P | 139 |
| Q352E | 371 |
| Y98C | 110 |
| A379T | 399 |
| G269R | 287 |
| A431V | 451 |
| S383P | 403 |
| P232S | 250 |
| S17T | 26 |
| A93T | 105 |
| N133T | 145 |
| D36E | 48 |
| A110V | 122 |
| A139V | 151 |
| G300W | 319 |
| H276M | 294 |
| Q295H | 314 |
| S17N | 26 |
| G19D | 28 |
| Q224E | 242 |
| A243S | 261 |
| A550D | 570 |
| P2S | 10 |
| S140N | 152 |
| G279D | 297 |
| G285D | 304 |
| G316D | 335 |
| S457I | 477 |
| G593D | 613 |
| Q127E | 139 |
| D735N | 756 |
| G629S | 649 |
| L587M | 607 |
| S315R | 334 |
| S315G | 334 |
| A350S | 369 |
| Y337C | 356 |
| W328G | 347 |
| T275P | 293 |
| T262R | 280 |
| S315I | 334 |
| M126I | 138 |
| S315N | 334 |
| H97R | 109 |
| N596S;Y597H | 616;617 |
| V473F | 493 |
| V473W | 493 |
| V473Y | 493 |
| V473G | 493 |
| V473N | 493 |
| V473S | 493 |
| V473M | 493 |
| V473R | 493 |
| V473K | 493 |
| V473I | 493 |
| V473D | 493 |
| A234G | 252 |
| V68G | 80 |
| W300G | 319 |
| Y229F | 247 |
| N138S | 150 |
| N138D | 150 |
| H108Q | 120 |
| H108E | 120 |
| W107R | 119 |
| R104L | 116 |
| D63E | 75 |
| D194Y | 206 |
| P131Q | 143 |
| S303L | 322 |
| S303C | 322 |
| D311N | 330 |
| D311S | 330 |
| L427I | 447 |
| L430V | 450 |
| R128Q | 140 |
| R489S | 509 |
| M420T | 440 |
| D387H | 407 |
| G123E | 135 |
| G299S | 318 |
| D419H | 439 |
| M176T | 188 |
| R632C | 652 |
| D542H | 562 |
| Y64S | 76 |
| Y95C | 107 |
| P131T | 143 |
| A139P | 151 |
| D142G | 154 |
| R418L | 438 |
| W328F | 347 |
| W321F | 340 |
| T275V | 293 |
| A162V | 174 |
| P501A | 521 |
| Q525P | 545 |
| L587P | 607 |
| S700P | 721 |