ompF - ARO:3003390-NP_415449.1
Structure
Entry features
| GENE | ompF | |
|---|---|---|
| DESCRIPTION | Outer membrane protein 1A | |
| ORGANISM | Escherichia coli str. K-12 substr. MG1655 | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. | |
| UNIPROT | P02931 | |
| NCBI | NP_415449.1 | |
| ARO term | ARO:3003390 | |
| RESISTANCE | carbapenem; cefepime; cephalosporin; cephamycin; monobactam; penam; penem |
Cross-references
| STRING | 316385.ECDH10B_0999 | |
|---|---|---|
| REFSEQ | NP_415449.1; NC_000913.3; WP_000977920.1; NZ_LN832404.1 | |
| PFAM | PF00267 - Porin_1 | |
| PATRIC | fig|1411691.4.peg.1347 | |
| KEGG | ecj:JW0912; eco:b0929 | |
| EMBL | AP009048; BAA35675.1; J01655; AAA24244.1; U00096; AAC74015.1 | |
| BioCyc/EcoCyc/MetaCyc | EcoCyc:EG10671-MONOMER; MetaCyc:EG10671-MONOMER | |
| INTACT | P02931 | |
| Drugbank | DB04233 - (Hydroxyethyloxy)Tri(Ethyloxy)Octane | |
| MINT | P02931 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0005216 | F:ion channel activity | IDA | |
| GO:0015075 | F:ion transmembrane transporter activity | TAS | |
| GO:0015238 | F:drug transmembrane transporter activity | IMP | |
| GO:0015288 | F:porin activity | IMP | |
| GO:0042802 | F:identical protein binding | IDA | |
| GO:0042912 | F:colicin transmembrane transporter activity | IMP | |
| GO:0047485 | F:protein N-terminus binding | IPI | |
| GO:0097718 | F:disordered domain specific binding | IPI | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006855 | P:drug transmembrane transport | IMP | |
| GO:0034220 | P:ion transmembrane transport | IDA | |
| GO:0070207 | P:protein homotrimerization | IDA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0009279 | C:cell outer membrane | IDA | |
| GO:0016021 | C:integral component of membrane | IDA | |
| GO:0034702 | C:ion channel complex | IDA | |
| GO:0046930 | C:pore complex | IDA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| G141D | resistant | PMID:10639355 |
| G141E | resistant | PMID:10639355 |
| R154A | resistant | PMID:10639355 |
| R154D | resistant | PMID:10639355 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| G141D | 142 |
| G141E | 142 |
| R154A | 156 |
| R154D | 156 |