marR - ARO:3003378-AAC74603.2
Structure
Entry features
| GENE | marR |
|---|---|
| ORGANISM | Escherichia coli str. K-12 substr. MG1655 |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. |
| UNIPROT | P27245 |
| NCBI | AAC74603.2 |
| ARO term | ARO:3003378 |
| RESISTANCE | cephalosporin; fluoroquinolone; glycylcycline; penam; phenicol; rifamycin; tetracycline; triclosan |
Cross-references
| STRING | 316385.ECDH10B_1661 |
|---|---|
| REFSEQ | NP_416047.4; NC_000913.3; WP_000843414.1; NZ_LN832404.1 |
| PFAM | PF01047 - MarR |
| PATRIC | fig|1411691.4.peg.736 |
| KEGG | ecj:JW5248; eco:b1530 |
| EMBL | AP009048; BAA15220.1; M96235; AAC16394.2; U00096; AAC74603.2 |
| BioCyc/EcoCyc/MetaCyc | EcoCyc:PD00364 |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IDA | |
| GO:0003700 | F:DNA-binding transcription factor activity | IEA | |
| GO:0044212 | F:transcription regulatory region DNA binding | IBA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006351 | P:transcription, DNA-templated | IEA | |
| GO:0009408 | P:response to heat | IMP | |
| GO:0045892 | P:negative regulation of transcription, DNA-templated | IMP | |
| GO:0071236 | P:cellular response to antibiotic | IMP |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| A70T | resistant | PMID:PMID in progress (single) |
| G103S | resistant | PMID:8807064 |
| I49S | resistant | PMID:9687412 |
| L78M | resistant | PMID:9687412 |
| R58L | resistant | PMID:8550435 |
| R73C | resistant | PMID:PMID in progress (single) |
| R73S | resistant | PMID:PMID in progress (single) |
| R77C | resistant | PMID:PMID in progress (single) |
| R77L | resistant | PMID:PMID in progress (single) |
| R94H | resistant | PMID:9687412 |
| R94S | resistant | PMID:9687412 |
| S3N | resistant | PMID:8807064 |
| V45E | resistant | PMID:PMID in progress (single) |
| V96E | resistant | PMID:8807064 |
| Y137H | resistant | PMID:PMID in progress (single) |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| A70T | 70 |
| G103S | 103 |
| I49S | 49 |
| L78M | 78 |
| R58L | 58 |
| R73C | 73 |
| R73S | 73 |
| R77C | 77 |
| R77L | 77 |
| R94H | 94 |
| R94S | 94 |
| S3N | 3 |
| V45E | 45 |
| V96E | 96 |
| Y137H | 137 |