parE - ARO:3003316-WP_000195296.1
Structure
Entry features
| GENE | parE | |
|---|---|---|
| DESCRIPTION | Topoisomerase IV subunit B | |
| ORGANISM | Proteobacteria | |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Enterobacteriaceae; Escherichia. | |
| UNIPROT | A0A0H3MKL3 | |
| NCBI | WP_000195296.1 | |
| ARO term | ARO:3003316 | |
| RESISTANCE | ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin; quinolone |
Cross-references
| REFSEQ | WP_000195296.1; NC_011750.1; YP_002409433.1 | |
|---|---|---|
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| PATRIC | fig|585057.6.peg.3654 | |
| KEGG | ect:ECIAI39_3527 | |
| EMBL | CU928164; CAR19643.1 | |
| BioCyc/EcoCyc/MetaCyc | ECOL585057:ECIAI39_3527-MONOMER | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_00938 ; ECO:0000256| SAAS:SAAS00924961 | |
| NUCLEOTIDE BINDING | 110 116 ATP |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0007059 | P:chromosome segregation | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| D476N | resistant | PMID:25631675 |
| L445H | resistant | PMID:NA |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D476N | 476 |
| L445H | 445 |