parC - ARO:3003311-AAK74984.1
Structure
Entry features
| GENE | parC | |
|---|---|---|
| DESCRIPTION | Topoisomerase IV subunit A | |
| ORGANISM | Streptococcus pneumoniae TIGR4 | |
| TAXONOMY | Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;Streptococcus. | |
| UNIPROT | P72525 | |
| NCBI | AAK74984.1 | |
| ARO term | ARO:3003311 | |
| RESISTANCE | ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| PFAM | PF00521 - DNA_topoisoIV; PF03989 - DNA_gyraseA_C | |
|---|---|---|
| KEGG | spn:SP_0855 | |
| EMBL | AE005672; AAK74984.1; U49088; AAB08038.1; X95717; CAA65021.1; Z67739; CAA91551.2 | |
| INTACT | P72525 | |
| EC | 5.99.1.3 | |
| Drugbank | DB01044 - Gatifloxacin; DB06771 - Besifloxacin | |
| CHEMBL | CHEMBL2363033 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000255| HAMAP-Rule:MF_00937 ; ECO:0000269| PubMed:17375187 ; ECO:0000269| PubMed:20596531 | |
| Active site | 118 118 O-(5'-phospho-DNA)-tyrosine intermediate |
Gene Ontology
| Molecular Function | GO ID | Term | Evidence |
|---|---|---|---|
| GO:0003677 | F:DNA binding | IEA | |
| GO:0003918 | F:DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | |
| GO:0005524 | F:ATP binding | IEA | |
| Biological Process | GO ID | Term | Evidence |
| GO:0006265 | P:DNA topological change | IEA | |
| GO:0007059 | P:chromosome segregation | IEA | |
| Cellular Component | GO ID | Term | Evidence |
| GO:0005694 | C:chromosome | IEA | |
| GO:0019897 | C:extrinsic component of plasma membrane | IEA |
Mutation panel
| Mutation | Phenotype | Reference |
|---|---|---|
| D84H | resistant | PMID:8913454 |
| S80F | resistant | PMID:8913454 |
| S80Y | resistant | PMID:8913454 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| D84H | 84 |
| S80F | 80 |
| S80Y | 80 |