gyrB - ARO:3003306-WP_004236715.1
Model based on:
Entry features
| GENE | gyrB |
|---|---|
| ORGANISM | Morganella |
| TAXONOMY | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;Morganellaceae; Morganella. |
| UNIPROT | A0A2X1TYS9 |
| NCBI | WP_004236715.1 |
| ARO term | ARO:3003306 |
| Template | 4JUO C |
| RESISTANCE | aminocoumarin; ciprofloxacin; enoxacin; fluoroquinolone; gatifloxacin; grepafloxacin; levofloxacin; lomefloxacin; moxifloxacin; nalidixic acid; norfloxacin; ofloxacin; pefloxacin; sparfloxacin; trovafloxacin |
Cross-references
| REFSEQ | WP_004236715.1; NZ_NXIQ01000005.1 | |
|---|---|---|
| PFAM | PF00204 - DNA_gyraseB; PF00986 - DNA_gyraseB_C; PF01751 - Toprim; PF02518 - HATPase_c | |
| EMBL | UASY01000007; SPX73874.1 | |
| EC | 5.99.1.3 | |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA; ECO:0000256| HAMAP-Rule:MF_01898 ; ECO:0000256| SAAS:SAAS00924961 |
Mutation panel
| Mutation | Phenotype | Reference | Map mutation on Model |
|---|---|---|---|
| S463A | resistant | PMID:25106550 | 446 |
| S464Y | resistant | PMID:25106550 | 447 |
Sequence
Multiple sequence alignment
MSA Mutation
| Variant | Position in MSA |
|---|---|
| S463A | 470 |
| S464Y | 471 |